Evidence that the ATR/Chk 1 pathway maintains normal replication fork progression during unperturbed S phase

Petermann, Eva and Caldecott, Keith W (2006) Evidence that the ATR/Chk 1 pathway maintains normal replication fork progression during unperturbed S phase. Cell Cycle, 5 (19). pp. 2203-2209. ISSN 1551-4005

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Abstract

If cells are treated with DNA damaging agents or inhibitors that interfere with ongoing DNA replication, the intra-S and S/M checkpoints delay progression through S phase and mitotic entry, respectively, to allow time for DNA repair and replication restart. In vertebrates, these checkpoint responses to replication blocks are largely mediated by the sensor kinase ATR and its major downstream effector kinase Chk1. Increasing evidence suggests that the ATR pathway is also vital in the absence of exogenous stresses, i.e., during "unperturbed" replication. Both ATR and Chk1 are essential proteins in vertebrates, and lack of components of the ATR/Chk1 pathway can result in impaired replication and spontaneous DNA damage. Here we give an overview of how the ATR/Chk1 pathway responds to exogenously blocked replication and then describe evidence for roles of this pathway during replication in an unperturbed S phase.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Keith Caldecott
Date Deposited: 06 Feb 2012 19:43
Last Modified: 30 Mar 2012 11:04
URI: http://srodev.sussex.ac.uk/id/eprint/21904
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