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Mouse models for ATR deficiency

journal contribution
posted on 2023-06-07, 15:17 authored by Mark O'DriscollMark O'Driscoll
ATM and ATR orchestrate overlapping DNA damage responses in reply to different forms of DNA strand discontinuities. But, knockout mouse models suggest that ATR is essential for viability in contrast to ATM. Recently, more sophisticated mouse models have been published including a conditional ATR-knockdown system and by modelling the human ATR-Seckel syndrome-causative mutation. Here, I will overview and contrast these models highlighting the advances both represent in our understanding of how defects in the ATR-dependent DNA damage response can impact on normal development, tissue homeostasis, ageing and cancer. © 2009 Elsevier B.V. All rights reserved.

History

Publication status

  • Published

Journal

DNA Repair

ISSN

1568-7864

Publisher

Elsevier

Issue

11

Volume

8

Page range

1333-1337

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Notes

GDSC314

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2010-04-08

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