Normal subcellular distribution of dynein-dynactin complex subunits and disturbances in neurodegenerative disease

Ateh, D D, Hussain, I, Mustafa, A, Price, K M, Nickols, C D, Bird, M M, Greensmith, L, Schiavo, G, Hafezparast, M, Fisher, E M C, Baker, C S and Martin, J E (2006) Normal subcellular distribution of dynein-dynactin complex subunits and disturbances in neurodegenerative disease. Neuropathology and Applied Neurobiology, 32 (2). pp. 234-235. ISSN 0305-1846

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Abstract

Dynein and its co-factor dynactin form a complex which drives the retrograde transport of material in neurons necessary for their survival and proper functioning. For instance, over-expression of the dynamitin subunit or mutations within individual dynein-dynactin subunits have been found to cause motor neuron degeneration. The CNS distribution of the dynein dynactin complex was examined in order to test the hypothesis that this may be altered in neurodegenerative diseases.

Item Type: Article
Additional Information: Meeting Abstract from 107th Meeting of the British Neuropathological Society, London, UK. 11-13th Januray, 2006.
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 19:57
Last Modified: 30 Nov 2012 17:05
URI: http://srodev.sussex.ac.uk/id/eprint/23203
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