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Intra-accumbens baclofen, but not muscimol, mimics the effects of food withdrawal on the behavioural satiety sequence
journal contribution
posted on 2023-06-08, 00:59 authored by K. G. T. Pulman, E. M. Somerville, Pete CliftonPete CliftonIntra-accumbens stimulation of GABA receptors results in a robust increase in food intake. However the differential consequences of stimulating GABA(A) and GABA(B) receptors in the nucleus accumbens have not been extensively explored with respect to feeding behaviour. Here we compare the effects of the GABA(B) receptor agonist baclofen and GABA(A) receptor agonist muscimol, infused into the nucleus accumbens shell, on food intake and related behavior patterns. Baclofen (110–440 ?mol) dose dependently enhanced intake and delayed the onset of satiety within the test period as did the effects of 4–8 h food withdrawal. Muscimol (220–660 ?mol) enhanced intake but also disrupted the sequence of associated behaviours at every dose tested. We conclude that GABA(B) receptors in the nucleus accumbens shell may play a role in relation to feeding motivation whereas GABA(A) receptors may, as previously suggested, have a more restricted role in relation to the motor components of approach to food and ingestion.
History
Publication status
- Published
Journal
Pharmacology Biochemistry and BehaviorISSN
0091-3057Publisher
ElsevierExternal DOI
Issue
1Volume
97Page range
156-162Department affiliated with
- Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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