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Divergent Requirements for the MAPKERK Signal Transduction Pathway during Initial Virus Infection of Quiescent Primary B Cells and Disruption of Epstein-Barr Virus Latency by Phorbol Esters
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posted on 2023-06-08, 05:11 authored by Mandy Fenton, Alison SinclairQuiescent primary B lymphocytes and Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines express components of the extracellular response kinase arm of the mitogen-activated protein kinase (MAPK(ERK)) Signal transduction pathway and transmit signals through the pathway when exposed to appropriate stimuli. Although the MAPK(ERK) pathway is activated following infection with EBV, MAPK/ERK kinase (MEK1) activity is not required to drive the proliferation of infected cells. However, MEK1 contributes to EBV latency control.
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Publication status
- Published
Journal
Journal of VirologyISSN
0022-538XPublisher
American Society for MicrobiologyPublisher URL
Issue
10Volume
73Page range
8913-8916ISBN
0022-538xDepartment affiliated with
- Biochemistry Publications
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The most prestigious journal concerning virologyFull text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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