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Tolerance and M2 (alternative)macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB

journal contribution
posted on 2023-06-07, 15:34 authored by Chiara Porta, Monica Rimoldi, Geert Raes, Lea Brys, Pietro Ghezzi, Diana Di Liberto, Serena Ghisletti, Gioacchino Natoli, Patrick De Baetselier, Alberto Mantovani, Antonio Sica
Cells of the monocyte–macrophage lineage play a central role in the orchestration and resolution of inflammation. Plasticity is a hallmark of mononuclear phagocytes, and in response to environmental signals these cells undergo different forms of polarized activation, the extremes of which are called classic or M1 and alternative or M2. NF-?B is a key regulator of inflammation and resolution, and its activation is subject to multiple levels of regulation, including inhibitory, which finely tune macrophage functions. Here we identify the p50 subunit of NF-?B as a key regulator of M2-driven inflammatory reactions in vitro and in vivo. p50 NF-?B inhibits NF-?B–driven, M1-polarizing, IFN-ß production. Accordingly, p50-deficient mice show exacerbated M1-driven inflammation and defective capacity to mount allergy and helminth-driven M2-polarized inflammatory reactions. Thus, NF-?B p50 is a key component in the orchestration of M2-driven inflammatory reactions.

History

Publication status

  • Published

Journal

Proceedings of the National Academy of Sciences

ISSN

0027-8424

Publisher

National Academy of Sciences

Issue

35

Volume

106

Page range

14978-14983

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2010-10-25

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