Reply to Macaulay et al. (1999): mtDNA recombination - reasons to panic

Eyre-Walker, Adam, Smith, Noel H and Smith, John Maynard (1999) Reply to Macaulay et al. (1999): mtDNA recombination - reasons to panic. Proceedings B: Biological Sciences, 266 (1433). pp. 2041-2042. ISSN 0962-8452

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We recently presented evidence of recombination in human mitochondrial DNA (mtDNA) using a data set of largely complete human mtDNAs gleaned from GenBank and the literature. It was pointed out that some of the sequences are probably incorrect and that, when those sequences are removed, so too is the evidence of recombination. Nevertheless, we argue that there is still evidence of recombination. First, there are excessive numbers of homoplasies in other mtDNA data sets. Second, an expanded data set of our own, excluding the sequences which are the subject of suspicion, shows a significant excess of homoplasies and, hence, evidence of recombination.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 06 Feb 2012 20:20
Last Modified: 21 May 2012 13:59
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