Nitric oxide in septic shock

Titheradge, Michael (1999) Nitric oxide in septic shock. BBA - Bioenergetics, 1411 (2-3). pp. 437-455. ISSN 0005-2728

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Septic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world. It is characterised by hypotension and vascular collapse, with a failure of the major organs within the body. The role of excessive nitric oxide (NO) production, following the cytokine-dependent induction of the inducible nitric oxide synthase (iNOS), in the development of septic shock is discussed. Emphasis is placed upon the signal-transduction process by which iNOS is induced and the role of NO in cellular energy dysfunction and the abnormal function of the cardiovascular system and liver during septic shock.

Item Type: Article
Additional Information: Invited review in special issue on Nitric Oxide Biochemistry
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Michael Titheradge
Date Deposited: 06 Feb 2012 20:22
Last Modified: 16 Jul 2012 15:00
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