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Nonsense-mediated RNA decay: a molecular system micromanaging individual gene activities and suppressing genomic noise

journal contribution
posted on 2023-06-08, 06:16 authored by Claudio AlonsoClaudio Alonso
Nonsense-mediated RNA decay (NMD) is an evolutionary conserved system of RNA surveillance that detects and degrades RNA transcripts containing nonsense mutations. Given that these mutations arise at a relatively low frequency, are there any as yet unknown substrates of NMD in a wild-type cell? With this question in mind, Mendell et al. have used a microarray assay to identify those human genes under NMD regulation. Their results show that, in human cells, NMD regulates hundreds of physiologic transcripts and not just those containing nonsense mutations. Among the NMD targets are a number of non-functional RNAs expressed from vestigial sequences derived from retroviral and transposable elements. These findings support the notion that NMD is a high profile post-transcriptional mechanism micromanaging the activity of multiple gene batteries and suppressing the expression of genetic remnants. 2005 Wiley Periodicals, Inc.

History

Publication status

  • Published

Journal

BioEssays

ISSN

0265-9247

Publisher

Wiley-VCH Verlag Berlin

Issue

5

Volume

27

Page range

463-466

Pages

4.0

Department affiliated with

  • Evolution, Behaviour and Environment Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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