DNA single-strand breaks and neurodegeneration

Caldecott, Keith (2004) DNA single-strand breaks and neurodegeneration. DNA Repair, 3 (8-9). pp. 875-882. ISSN 1568-7864

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The association of human genetic disorders with defects in the DNA damage response is well established. Most of the major DNA repair pathways are represented by diseases in which that pathway is absent or impaired, including those responsible for repairing DNA double-strand breaks. Conspicuous by their absence, however, have been human disorders associated with defects in the repair or response to DNA single-strand breaks (SSBs). However, three papers have recently associated hereditary spinocerebellar ataxia with mutations in genes connected with SSBR. The emerging links between SSBR and neurodegeneration are discussed.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Keith Caldecott
Date Deposited: 06 Feb 2012 20:31
Last Modified: 24 Jul 2012 09:57
URI: http://srodev.sussex.ac.uk/id/eprint/26343
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