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The evolution of isochores
journal contribution
posted on 2023-06-08, 07:03 authored by Adam Eyre-WalkerAdam Eyre-Walker, Laurence D HurstOne of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.
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Publication status
- Published
Journal
Nature Reviews GeneticsISSN
1471-0056Publisher
Nature ResearchExternal DOI
Issue
7Volume
2Page range
549-555Pages
7.0Department affiliated with
- Evolution, Behaviour and Environment Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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