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Control of Central Synaptic Specificity in Insect Sensory Neurons
journal contribution
posted on 2023-06-08, 07:05 authored by Jonathan M Blagburn, Jonathan BaconSynaptic specificity is the culmination of several processes, beginning with the establishment of neuronal subtype identity, followed by navigation of the axon to the correct subdivision of neuropil, and finally, the cell-cell recognition of appropriate synaptic partners. In this review we summarize the work on sensory neurons in crickets, cockroaches, moths, and fruit flies that establishes some of the principles and molecular mechanisms involved in the control of synaptic specificity. The identity of a sensory neuron is controlled by combinatorial expression of transcription factors, the products of patterning and proneural genes. In the nervous system, sensory axon projections are anatomically segregated according to modality, stimulus quality, and cell-body position. A variety of cell-surface and intracellular signaling molecules are used to achieve this. Synaptic target recognition is also controlled by transcription factors such as Engrailed and may be, in part, mediated by cadherin-like molecules.
History
Publication status
- Published
Journal
Annual Review of NeuroscienceISSN
0147-006XVolume
27Page range
29-51Department affiliated with
- Evolution, Behaviour and Environment Publications
Notes
Jonathan Blagburn and I co-wrote this review and refer very heavily to our own work in this area.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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