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Viseux, E M E, Parsons, P J, Pavey, J B J, Carter, C M and Pinto, I (2003) Model studies towards the total synthesis of the anticancer agent roseophilin. SYNLETT, 2003 (12). pp. 1856-1858. ISSN 0936-5214
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Official URL: http://dx.doi.org/10.1055/s-2003-41498
Abstract
In our new approach to the anticancer agent roseophilin (1), a concise, stereocontrolled synthesis of the bicyclic model system 16 was achieved. Key steps include a diastereoselective Ireland-Claisen rearrangement and a stereoselective construction of the hexahydro-cyclopenta[b]pyrrol-6-one core via a tandem intramolecular aza-Wittig/[3+2]-cycloaddition sequence
Item Type: | Article |
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Additional Information: | EMEV did virtually all the synthetic work and co wrote the paper. This paper features an original tandem aza-Wittig / 1,3-dipolar cycloaddition to assemble bicyclic cores with full control over four chiral centers. This is currently applied to a route towards the total synthesis of the anticancer agent roseophilin. |
Schools and Departments: | School of Life Sciences > Chemistry |
Depositing User: | Eddy Viseux |
Date Deposited: | 06 Feb 2012 20:37 |
Last Modified: | 28 Mar 2012 08:47 |
URI: | http://srodev.sussex.ac.uk/id/eprint/27088 |