The zinc-responsive regulator Zur controls expression of the coelibactin gene cluster in Streptomyces coelicolor

Kallifidas, Dimitris, Pascoe, Ben, Owen, Gillian A, Strain-Damerell, Claire M, Hong, Hee-Jeon and Paget, Mark (2010) The zinc-responsive regulator Zur controls expression of the coelibactin gene cluster in Streptomyces coelicolor. Journal of Bacteriology, 192 (2). pp. 608-611. ISSN 0021-9193

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Abstract

Streptomyces coelicolor mutants lacking the zinc-responsive Zur repressor are conditionally defective in sporulation, presumably due to the overexpression of one or more Zur target genes. Gene disruption analyses revealed that deregulation of previously known Zur targets was not responsible for the sporulation phenotype. We used microarrays to identify further Zur targets and discovered that Zur controls a cluster of genes predicted to direct synthesis of an uncharacterized siderophore-related non-ribosomally encoded peptide designated coelibactin. Disruption of a key coelibactin biosynthetic gene suppressed the Zur sporulation phenotype, suggesting that deregulation of coelibactin synthesis inhibits sporulation.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science
Depositing User: Ben Pascoe
Date Deposited: 06 Feb 2012 20:39
Last Modified: 18 Oct 2012 09:59
URI: http://srodev.sussex.ac.uk/id/eprint/27243
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