Clubbing together on clamps: The key to translesion synthesis

Lehmann, Alan R. (2006) Clubbing together on clamps: The key to translesion synthesis. DNA Repair, 5 (3). pp. 404-407. ISSN 1568-7864

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Translesion synthesis is an important mechanism by which cells replicate past DNA damage. The sliding clamp DNA polymerase processivity factors play a central role in this process. The clamps are dimeric in bacteria and trimeric in eukaryotes and archaea, raising the question of whether more than one polymerase can interact with the clamp simultaneously. Recently published data suggest that this is indeed the case.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
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Depositing User: Alan Lehmann
Date Deposited: 06 Feb 2012 20:41
Last Modified: 24 Jul 2012 10:37
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