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Investigation of multimerisation region of the KSHV (HHV8) encoded protein K-bZIP: the proposed leucine zipper region encodes a multimerisation domain with an unusual structure
journal contribution
posted on 2023-06-08, 07:43 authored by Salama Al Mehairi, Eleonora Cerasoli, Alison SinclairThe K8 gene of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) shares many functional similarities with the BZLF1 gene of Epstein-Barr virus. The protein products of K8 and BZLF1, K-bZIP (RAP, K8) and Zta (BZLF1, ZEBRA, Z) have both been proposed to be members of the bZIP family of transcription factors, forming multimers via a coiled-coil motif termed a leucine zipper. Substantial evidence supporting this model for Zta is published. Here, we demonstrate that the proposed leucine zipper region of K-bZIP (amino acids 182 to 218) is required for multimer formation but that it does not fold as a coiled coil.
History
Publication status
- Published
Journal
Journal of VirologyISSN
0022-538XPublisher
American Society for MicrobiologyExternal DOI
Issue
12Volume
79Page range
7905-7910Pages
6.0Department affiliated with
- Biochemistry Publications
Notes
This research was undertaken in Dr Sinclair's laboratory. This is the first biophysical investigation of the K-bZIP protein encoded by KSHV. The conclusions presented alter the working model of the physical structure of K-bZIP.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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