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From genetics to pathology: tau and a-synuclein assemblies in neurodegenerative diseases
journal contribution
posted on 2023-06-08, 07:46 authored by Michel Goedert, Maria Grazia Spillantini, Louise SerpellLouise Serpell, John Berriman, Michael J Smith, Ross Jakes, R Anthony CrowtherThe most common degenerative diseases of the human brain are characterized by the presence of abnormal filamentous inclusions in affected nerve cells and glial cells. These diseases can be grouped into two classes, based on the identity of the major proteinaceous components of the filamentous assemblies. The filaments are made of either the microtubule¿associated protein tau or the protein a¿synuclein. Importantly, the discovery of mutations in the tau gene in familial forms of frontotemporal dementia and of mutations in the a¿synuclein gene in familial forms of Parkinson's disease has established that dysfunction of tau protein and a¿synuclein can cause neurodegeneration.
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Publication status
- Published
Journal
Philosophical Transactions B: Biological SciencesISSN
1471-2970Publisher
Royal Society, TheExternal DOI
Issue
1406Volume
356Page range
213-227Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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