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Nitric Oxide Regulates Cell Proliferation during Drosophila Development
journal contribution
posted on 2023-06-08, 07:49 authored by Boris Kuzin, Ian Roberts, Nalalia Peunova, Grigori EnikolopovCell division and subsequent programmed cell death in imaginal discs of Drosophila larvae determine the final size of organs and structures of the adult fly. We show here that nitric oxide (NO) is involved in controlling the size of body structures during Drosophila development. We have found that NO synthase (NOS) is expressed at high levels in developing imaginal discs. Inhibition of NOS in larvae causes hypertrophy of organs and their segments in adult flies, whereas ectopic expression of NOS in larvae has the opposite effect. Blocking apoptosis in eye imaginal discs unmasks surplus cell proliferation and results in an increase in the number of ommatidia and component cells of individual ommatidia. These results argue that NO acts as an antiproliferative agent during Drosophila development, controlling the balance between cell proliferation and cell differentiation
History
Publication status
- Published
Journal
CellISSN
1474-9718Publisher
CellExternal DOI
Issue
4Volume
87Page range
639-649ISBN
0092-8674Department affiliated with
- Biology and Environmental Science Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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