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Spike-timing-dependent plasticity of inhibitory synapses in the entorhinal cortex
journal contribution
posted on 2023-06-08, 07:55 authored by Julie S Haas, Thomas NowotnyThomas Nowotny, H D I AbarbanelActions of inhibitory interneurons organize and modulate many neuronal processes, yet the mechanisms and consequences of plasticity of inhibitory synapses remain poorly understood. We report on spike-timing-dependent plasticity of inhibitory synapses in the entorhinal cortex. After pairing presynaptic stimulations at time tpre with evoked postsynaptic spikes at time tpost under pharmacological blockade of excitation we found, via whole cell recordings, an asymmetrical timing rule for plasticity of the remaining inhibitory responses. Strength of response varied as a function of the time interval {Delta}t = tpost tpre: for {Delta}t > 0 inhibitory responses potentiated, peaking at a delay of 10 ms. For {Delta}t < 0, the synaptic coupling depressed, again with a maximal effect near 10 ms of delay. We also show that changes in synaptic strength depend on changes in intracellular calcium concentrations and demonstrate that the calcium enters the postsynaptic cell through voltage-gated channels. Using network models, we demonstrate how this novel form of plasticity can sculpt network behavior efficiently and with remarkable flexibility.
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Publication status
- Published
Journal
Journal of NeurophysiologyISSN
0022-3077Publisher
American Physiological SocietyExternal DOI
Issue
6Volume
96Page range
3305 - 3313Department affiliated with
- Informatics Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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