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The Drosophila miniature and dusky encode ZP-proteins required for cytoskeletal reorganisation during wing morphogenesis
journal contribution
posted on 2023-06-08, 08:05 authored by Fernando Roch, Claudio AlonsoClaudio Alonso, Michael AkamWe have characterised the function of two Drosophila genes, miniature and dusky, that are required for the morphological reorganisation of the apical membrane during wing epidermis differentiation. These genes encode transmembrane proteins containing a ZP (zona pellucida) domain and are homologous to several vertebrate and invertebrate apical matrix components. miniature and dusky are only expressed in tissues secreting a cuticle, and the Min protein localises to the apical membrane during the early stages of cuticle formation. We propose that Min and Dusky form a novel subfamily within the ZP domain proteins and are specifically involved in the interactions between the apical membrane, the cytoskeleton and the forming cuticle.
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Publication status
- Published
Journal
Journal of Cell ScienceISSN
0021-9533External DOI
Issue
7Volume
116Page range
1199-1207Department affiliated with
- Evolution, Behaviour and Environment Publications
Notes
I described a new family of ZP-proteins and their roles during the changes in cell morphology that lead to fly wing differentiationFull text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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