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Searching for sequence directed mutagenesis in eukaryotes.
journal contribution
posted on 2023-06-08, 08:29 authored by Emmanuel D Ladoukakis, Adam Eyre-WalkerAdam Eyre-WalkerSequence directed mutagenesis is a mechanism by which imperfect repeats ¿repair¿ each other to become perfect, generating mutations. This process is known to be prevalent in prokaryotes and it has been implicated in several human genetic diseases. Here we test whether sequence directed mutagenesis occurs in the protein coding sequences of eukaryotes using extensive DNA sequence data from humans, mice, Drosophila, nematodes, yeast, and Arabidopsis. Using two tests we find little evidence of sequence directed mutagenesis. We conclude that sequence directed mutagenesis is not prevalent in eukaryotes and that the examples of human diseases, apparently caused by sequence directed mutagenesis, are probably coincidental.
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Publication status
- Published
Journal
Journal of Molecular EvolutionISSN
0022-2844External DOI
Issue
1-3Volume
64Page range
1-3Pages
3.0Department affiliated with
- Evolution, Behaviour and Environment Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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