A complex 'mRNA degradation code' controls gene expression during animal development

Alonso, Claudio R (2012) A complex 'mRNA degradation code' controls gene expression during animal development. Trends in Genetics, 28 (2). pp. 78-88. ISSN 0168-9525

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Current understanding of the molecular mechanisms underlying mRNA degradation indicates that specific mRNA degradation rates are encoded within the mRNA message itself in the form of cis-regulatory elements bearing particular primary sequences and/or secondary-structures. Such control elements are operated by RNA-binding proteins (RBPs) and/or microRNA (miRNA)-containing complexes. Based on the large number of RBPs and miRNAs encoded in metazoan genomes, their complex developmental expression, and that specific RBP/miRNA interactions with mRNAs can lead to distinct degradation rates, I propose that developmental gene expression is shaped by a complex 'mRNA degradation code' with high information capacity. Localised cellular events involving the modification of RBP/miRNA target sequences in mRNAs by alternative polyadenylation and the activation of specific RBP/miRNA activities via cell signalling are predicted to further expand the capacity of the 'mRNA degradation code' by coupling it to dynamic events experienced by cells at specific spatio-temporal coordinates within the developing embryo

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Claudio Alonso
Date Deposited: 15 Feb 2013 12:50
Last Modified: 15 Feb 2013 12:50
URI: http://srodev.sussex.ac.uk/id/eprint/29133
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