Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron

Nikitin, E S, Kiss, T, Staras, K, O'Shea, M, Benjamin, P R and Kemenes, G (2006) Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron. Journal of Neurophysiology, 95 (1). pp. 453-463. ISSN 0022-3077

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Abstract

We have identified a TTX-resistant low-threshold persistent inward sodium current in the cerebral giant cells (CGCs) of Lymnaea, an important state-setting modulatory cell type of molluscan feeding networks. This current has slow voltage-dependent activation and de-activation kinetics, ultra-slow inactivation kinetics and fast de-inactivation kinetics. It activates at approximately -90 mV, peaks at approximately -30 mV, reverses at approximately +35 mV and does not show full voltage-dependent inactivation even at positive voltage steps. Lithium-sodium replacement experiments indicate that the persistent sodium current makes a significant contribution to the CGC membrane potential. Injection of cyclic adenosine monophosphate (cAMP) into the CGC cell body produces a large increase in the persistent sodium current that lasts for several hours. cAMP injection also leads to increased bursting, a significant decrease in the resistance and a significant depolarization of the soma membrane, indicating that cAMP-dependent mechanisms induce prolonged neuronal plasticity in the CGCs. Our observations provide the first link between cAMP-mediated modulation of a TTX-resistant persistent sodium current and prolonged neuronal plasticity in an identified modulatory cell type that plays an important role in behavioral state setting.

Item Type: Article
Additional Information: Senior author
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: Kevin Staras
Date Deposited: 06 Feb 2012 21:11
Last Modified: 04 May 2012 14:39
URI: http://srodev.sussex.ac.uk/id/eprint/30064
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