File(s) not publicly available
The molecular evolution of vertebrate growth hormones: a pattern of near-stasis interrupted by sustained bursts of rapid change
journal contribution
posted on 2023-06-08, 09:19 authored by Michael WallisIt has been demonstrated previously that in mammals the evolution of pituitary growth hormone shows an unusual pattern, with an underlying slow rate and at least two sustained bursts of rapid evolution (in the artiodactyls and primates), during which the rate increased at least 25-fold. It is demonstrated here that a similar pattern applies for growth hormone evolution throughout the vertebrates, with a basal rate similar to that seen in mammals, but bursts of rapid evolution in the amphibia and the elasmobranchs, and several bursts in the teleosts. The placental growth-hormone-like proteins of primates show a similar pattern. It is argued that the bursts of evolution seen for growth hormone are a consequence of selection and that this may reflect changes in the functions of the hormone additional to its basic growth-promoting actions.
History
Publication status
- Published
Journal
Journal of Molecular EvolutionISSN
0022-2844Publisher
Springer VerlagExternal DOI
Issue
2Volume
43Page range
93-100ISBN
0022-2844Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC