The Y-family DNA polymerase κ (pol κ) functions in mammalian nucleotide-excision repair

Ogi, Tomoo and Lehmann, Alan R (2006) The Y-family DNA polymerase κ (pol κ) functions in mammalian nucleotide-excision repair. Nature Cell Biology, 8 (6). pp. 640-642. ISSN 1465-7392

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Abstract

DNA polymerase ¿ (pol ¿) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage. Here, we show that pol ¿-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair (NER) of UV damage, as measured by several methods. Our results provide evidence for an unexpected role for pol ¿ in mammalian NER.

Item Type: Article
Additional Information: Work carried out entirely in my lab. Describes unexpected discovery of role for a Y-family polymerase in nucleotide excision repair.
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Alan Lehmann
Date Deposited: 06 Feb 2012 21:14
Last Modified: 03 Apr 2012 10:51
URI: http://srodev.sussex.ac.uk/id/eprint/30450
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