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Mammalian Single-Strand Break Repair; Mechanisms and Links with Chromatin

journal contribution
posted on 2023-06-08, 09:54 authored by Keith CaldecottKeith Caldecott
Thousands of cellular single-strand breaks (SSBs) arise in cells each day, from attack of deoxyribose and DNA bases by reactive oxygen species and other electrophilic molecules, and from the intrinsic instability of DNA. If not repaired, SSBs can disrupt transcription and replication and can be converted into potentially clastogenic and/or lethal DNA double-strand breaks. Here, I present an updated model for the repair of SSBs, and speculate on the possible impact of chromatin structure and remodelling on single-strand break repair (SSBR) processes.

History

Publication status

  • Published

Journal

DNA Repair

ISSN

1568-7864

Publisher

Elsevier

Issue

4

Volume

6

Page range

443-453

Pages

11.0

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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