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Regulation of transcription by the Epstein-Barr virus nuclear antigen EBNA 2

journal contribution
posted on 2023-06-08, 11:24 authored by Richard D Palermo, Helen WebbHelen Webb, Andrea Gunnell, Michelle WestMichelle West
The EBNA 2 (Epstein-Barr nuclear antigen 2) transcription factor is essential for B-cell transformation by the cancer-associated EBV (Epstein-Barr virus) and for the continuous proliferation of infected cells. EBNA 2 activates transcription from the viral Cp (C promoter) during infection to generate the 120 kb transcript that encodes all nuclear antigens required for immortalization by EBV. EBNA 2 contains an acidic activation domain and can interact with a number of general transcription factors and co-activators. It is now becoming clear, however, that the regulation of transcription elongation in addition to initiation by EBNA 2, at least in part through CDK9 (cyclin-dependent kinase 9)-dependent phosphorylation of the RNA polymerase C-terminal domain, is likely to play a crucial role in the mechanism of action of this key viral protein.

History

Publication status

  • Published

Journal

Biochemical Society Transactions

ISSN

0300-5127

Publisher

Portland Press

Issue

4

Volume

36

Page range

625-8

Department affiliated with

  • Biochemistry Publications

Research groups affiliated with

  • Haematology Research Group Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-05-03

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