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Cancer and the bromodomains of BAF180

journal contribution
posted on 2023-06-08, 11:25 authored by Peter M Brownlee, Anna L Chambers, Antony OliverAntony Oliver, Jessica A Downs
Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.

History

Publication status

  • Published

Journal

Biochemical Society Transactions

ISSN

0300-5127

Publisher

Portland Press

Issue

2

Volume

40

Page range

364-369

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-04-25

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