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Cancer and the bromodomains of BAF180
journal contribution
posted on 2023-06-08, 11:25 authored by Peter M Brownlee, Anna L Chambers, Antony OliverAntony Oliver, Jessica A DownsChromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180, which may function to target the PBAF complex to promoters or sites of DNA repair. In the present review, we discuss what is currently known about the BDs of BAF180 and their potential significance in cancer.
History
Publication status
- Published
Journal
Biochemical Society TransactionsISSN
0300-5127Publisher
Portland PressExternal DOI
Issue
2Volume
40Page range
364-369Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-04-25Usage metrics
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