Stanley, Mathew, Cattle, Nicholas, McCauley, John, Martin, Stephen R, Rashid, Abdul, Field, Robert A, Carbain, Benoit and Streicher, Hansjoerg (2012) ‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin). MedChemComm. ISSN 2040-2503

Full text not available from this repository.

Abstract

The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka Tamiflu) pharmacophore{,} to wild-type and resistant influenza virus strains{,} including isolates from the 2009 pandemic{,} is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as vantage point for novel influenza virus sensors{,} due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Biochemistry
Subjects:	Q Science > QD Chemistry > QD0241 Organic chemistry
Depositing User:	Hans Streicher
Date Deposited:	19 Jul 2012 09:57
Last Modified:	19 Jul 2012 09:57
URI:	http://srodev.sussex.ac.uk/id/eprint/39276

📧 Request an update