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Chapter 10: Regulators of G Protein Signaling in Neuropsychiatric Disorders
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posted on 2023-06-08, 11:42 authored by Dimitra Terzi, Eugenia Stergiou, Sarah KingSarah King, Venetia ZachariouRegulators of G protein signaling (RGS) comprise a diverse group of about 40 proteins which determine signaling amplitude and duration via modulation of receptor/G protein or receptor/effector coupling. Several members of the RGS family are expressed in the brain, where they have precise roles in regulation of important physiological processes. The unique functions of each RGS can be attributed to its structure, distinct pattern of expression, and regulation, and its preferential interactions with receptors, Ga subunits and other signaling proteins. Evidence suggests dysfunction of RGS proteins is related to several neuropathological conditions. Moreover, clinical and preclinical work reveals that the efficacy and/or side effects of treatments are highly influenced by RGS activity. This article summarizes findings on RGS proteins in vulnerability to several neuropsychiatric disorders, the mechanism via which RGS proteins control neuronal responses and their potential use as drug targets.
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Publication status
- Published
Publisher
Elsevier ScienceExternal DOI
Volume
86Page range
299-333Pages
366.0Book title
Molecular Biology of RGS ProteinsPlace of publication
LondonISBN
9780123747594Series
Progress in Molecular Biology and Translational ScienceDepartment affiliated with
- Psychology Publications
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- No
Peer reviewed?
- Yes
Editors
Rory A FisherLegacy Posted Date
2012-05-28Usage metrics
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