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Chapter 10: Regulators of G Protein Signaling in Neuropsychiatric Disorders

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posted on 2023-06-08, 11:42 authored by Dimitra Terzi, Eugenia Stergiou, Sarah KingSarah King, Venetia Zachariou
Regulators of G protein signaling (RGS) comprise a diverse group of about 40 proteins which determine signaling amplitude and duration via modulation of receptor/G protein or receptor/effector coupling. Several members of the RGS family are expressed in the brain, where they have precise roles in regulation of important physiological processes. The unique functions of each RGS can be attributed to its structure, distinct pattern of expression, and regulation, and its preferential interactions with receptors, Ga subunits and other signaling proteins. Evidence suggests dysfunction of RGS proteins is related to several neuropathological conditions. Moreover, clinical and preclinical work reveals that the efficacy and/or side effects of treatments are highly influenced by RGS activity. This article summarizes findings on RGS proteins in vulnerability to several neuropsychiatric disorders, the mechanism via which RGS proteins control neuronal responses and their potential use as drug targets.

History

Publication status

  • Published

Publisher

Elsevier Science

Volume

86

Page range

299-333

Pages

366.0

Book title

Molecular Biology of RGS Proteins

Place of publication

London

ISBN

9780123747594

Series

Progress in Molecular Biology and Translational Science

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Editors

Rory A Fisher

Legacy Posted Date

2012-05-28

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