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Horne, Robert, Clatworthy, Jane and Hankins, Matthew (2010) High adherence and concordance within a clinical trial of antihypertensives. Chronic Illness, 6 (4). pp. 243-251. ISSN 1742-3953
Full text not available from this repository.Abstract
Objectives: To explore hypertensive patients 19 beliefs about their condition and its treatment and their adherence within the context of a clinical trial. To assess the degree of concordance between patients 19 beliefs about hypertension and the medical model of the condition.
Methods: This was a questionnaire-based study, involving 230 patients participating in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), a randomized controlled trial comparing two pharmaceutical approaches to the management of hypertension. A comparison group of 106 hypertensive patients who were screened for ASCOT but did not meet the entry criteria was also recruited. Outcome measures were beliefs about hypertension and antihypertensive medication, and adherence to medication (self-report and tablet count).
Results: Adherence to medication was higher than anticipated, with 45% participants reporting complete adherence over the 18-month study and a further 40% only rare non-adherence. Patients 19 beliefs about their condition and treatment were generally concordant with the medical model of hypertension. High concordance was associated with high medication adherence (p<0.001).
Discussion: Clinical trial volunteers may have beliefs that are unusually concordant with the medical model of hypertension and may demonstrate atypically high adherence. This has implications for the transferability of trial findings to the general hypertensive population.
| Item Type: | Article |
|---|---|
| Keywords: | Adherence, Clinical trial, Hypertension, Illness perceptions, Treatment perceptions |
| Schools and Departments: | Brighton and Sussex Medical School > Primary Care and Public Health |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Jessica Stockdale |
| Date Deposited: | 13 Jul 2012 09:51 |
| Last Modified: | 13 Jul 2012 09:51 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/40103 |