University of Sussex
Browse
1/1
4 files

From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein

journal contribution
posted on 2023-06-08, 12:09 authored by Laurie Crossley, Caroline A Garrett, Majid HafezparastMajid Hafezparast, Anotida MadzvamuseAnotida Madzvamuse
Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed. We sought to develop a novel model which could incorporate the effects of mutations on distance travelled and velocity. A mechanical model for the dynein mediated transport of endosomes is derived from first principles and solved numerically. The effects of variations in model parameter values are analysed to find those that have a significant impact on velocity and distance travelled. The model successfully describes the processivity of dynein and matches qualitatively the velocity profiles observed in experiments.

History

Publication status

  • Published

Journal

Bulletin of Mathematical Biology

ISSN

1522-9602

Publisher

Springer Verlag

Issue

9

Volume

74

Page range

2032-2061

Department affiliated with

  • Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2012-08-07

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC