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The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults

journal contribution
posted on 2023-06-08, 12:13 authored by Jason Cunningham, Kaninika Basu, Roger Tavendale, Colin N A Palmer, Helen Smith, Somnath MukhopadhyaySomnath Mukhopadhyay
Background: Asthma exacerbations are the commonest cause of medical admissions in childhood. These have a significant effect on quality of life and are a major financial burden on worldwide healthcare services. A range of gene–environment interactions may influence the course and severity of asthma in children and their response to medication. The Chitinase 3-like 1 (CHI3L1)-131C>G genotype (rs4950928) is associated with increased asthma susceptibility and severity in adults Objectives: To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma. Methods: A cross-sectional survey was undertaken using medical records and direct interviews of 1,071 children and young adults with asthma, aged 3 to 22 years, from Scotland. Saliva samples were collected for genotyping. Binary logistic regression was used to calculate odds ratios (ORs) and P-values for measures of asthma exacerbations. Results: The minor -131G allele confers protection against asthma-related hospital admissions (OR = 0.62; 95% CI 0.41–0.92; P = .018) in children and young adults with asthma. Conclusions: Our study shows that rs4950928 is significantly associated with hospital admissions in children and young adults; screening for rs4950928 may predict asthma-related hospital admissions, and through individually defined treatment management plans, potentially reduce health care costs.

History

Publication status

  • Published

Journal

Annals of Allergy, Asthma and Immunology

ISSN

1081-1206

Publisher

Elsevier

Issue

5

Volume

106

Page range

381-386

Department affiliated with

  • Primary Care and Public Health Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-08-09

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