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Electrical properties of breast cancer cells from impedance measurement of cell suspensions

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posted on 2023-06-08, 12:27 authored by G Qiao, W Duan, Chris ChatwinChris Chatwin, Alison Sinclair, W Wang
Impedance spectroscopy of biological cells has been used to monitor cell status, e.g. cell proliferation, viability, etc. It is also a fundamental method for the study of the electrical properties of cells which has been utilised for cell identification in investigations of cell behaviour in the presence of an applied electric field, e.g. electroporation. There are two standard methods for impedance measurement on cells. The use of microelectrodes for single cell impedance measurement is one method to realise the measurement, but the variations between individual cells introduce significant measurement errors. Another method to measure electrical properties is by the measurement of cell suspensions, i.e. a group of cells within a culture medium or buffer. This paper presents an investigation of the impedance of normal and cancerous breast cells in suspension using the Maxwell-Wagner mixture theory to analyse the results and extract the electrical parameters of a single cell. The results show that normal and different stages of cancer breast cells can be distinguished by the conductivity presented by each cell. © 2010 IOP Publishing Ltd.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Physics: Conference Series

ISSN

1742-6588

Publisher

IOP Publishing

Issue

1

Volume

224

Department affiliated with

  • Engineering and Design Publications

Notes

14th International Conference on Electrical Bioimpedance, Held in Conjunction with the 11th Conference on Biomedical Applications of EIT, ICEBI and EIT 2010;Gainesville, FL;4 April 2010 through 8 April 2010; Code81124

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-28

First Open Access (FOA) Date

2016-03-22

First Compliant Deposit (FCD) Date

2016-08-17