The plasma-occupancy relationship of the novel GABAA receptor benzodiazepine site ligand, alpha5IA, is similar in rats and primates

Atack, John R, Eng, Wai-Si, Gibson, Ray E, Ryan, Christine, Francis, Barbara, Sohal, Bindi, Dawson, Gerard R, Hargreaves, Richard J and Burns, H Donald (2009) The plasma-occupancy relationship of the novel GABAA receptor benzodiazepine site ligand, alpha5IA, is similar in rats and primates. British Journal of Pharmacology, 157 (5). pp. 796-803. ISSN 1476-5381

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Abstract

Rat plasma EC(50) values did not vary as a function of time indicating that alpha5IA dissociates readily for the GABA(A) receptor in vivo. These data also suggest that despite the different assays used (terminal assays of [(3)H]flumazenil in vivo binding in rats and [(123)I]iomazenil gamma-scintigraphy in anaesthetized rhesus monkeys), these techniques produced similar plasma alpha5IA EC(50) values (52 and 57 ngxmL(-1) respectively) and that the plasma-occupancy relationship for alpha5IA translates across these two species.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science
Depositing User: Deeptima Massey
Date Deposited: 26 Oct 2012 13:18
Last Modified: 31 Oct 2012 15:57
URI: http://srodev.sussex.ac.uk/id/eprint/40915
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