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De Silva, S, Hassan Ibrahim, MO, Austin, M, Newport, Melanie and Verma, Sumita (2012) Hepatitis E infection is an under recognized cause of acute decompensation in patients with chronic liver disease. Digestive and Liver Disease, 44 (11). pp. 930-934. ISSN 1590-8658
Full text not available from this repository.Abstract
Background/aims
We aimed to assess characteristics of patients with a positive hepatitis E virus serology with emphasis on acute on chronic liver disease.
Methods
This was a retrospective audit performed at a large teaching hospital.
Results
Of the 164 patients tested, 15(9.1%) had a positive serology (hepatitis E virus IgG and or IgM) of whom two also had a positive hepatitis E virus RNA. Six (42.8%) had underlying chronic liver disease and presented with deteriorating liver tests±decompensation. In one patient (16%) acute hepatitis E virus infection was the aetiology for the decompensation and in three the positive hepatitis E virus IgG was a reflection of prior subclinical infection. However, in two of the six patients with unexplained decompensation there was delay (150–270 days) in obtaining a hepatitis E virus serology, which may have resulted in a negative hepatitis E virus IgM at time of testing.
Conclusions
9.1% of patients presenting with abnormal liver tests at a large teaching hospital in south east England have a positive hepatitis E virus serology of whom 42.8% have acute on chronic liver disease. In 16% hepatitis E virus infection is the aetiology for the acute decompensation. This may be an under representation as in >30% of patients with unexplained decompensation there is considerable delay in requesting a hepatitis E virus serology.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Global Health and Infection |
| Subjects: | R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases |
| Related URLs: | |
| Depositing User: | Ellen Thomas |
| Date Deposited: | 06 Mar 2013 15:28 |
| Last Modified: | 21 Sep 2017 11:44 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/41054 |