Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher, Tizzard, Graham, Coles, Simon, Bingham, John, Hartley, John, Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333

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Abstract

1,3-Dihydro-2H-indol-2-one (1) undergoes microwave-mediated Knoevenagel condensations with 1,2,3,4,5- pentaphenylferrocene carboxaldehyde (2b) or (? 4 -tetraphenylcyclobutadiene)(? 5 -cyclopentadienylcarboxaldehyde)cobalt (2c) to a?ord metallocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-one 4 or 5, respectively, in excellent yields as separable E,Z-stereoisomeric mixtures. Both 4 and 5 exhibited poor kinase inhibition and no appreciable cytotoxicity toward a leukemia cell line, attributed to the steric bulk of the metallocene substituents.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
Subjects:	Q Science
Depositing User:	Deeptima Massey
Date Deposited:	22 Oct 2012 11:13
Last Modified:	22 Oct 2012 11:13
URI:	http://srodev.sussex.ac.uk/id/eprint/41262

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