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Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation?

journal contribution
posted on 2023-06-08, 12:41 authored by B Sierra, A B Perez, K Vogt, G Garcia, K Schmolke, E Aguirre, M Alvarez, Florian KernFlorian Kern, G Kouri, H D Volk, M G Guzman
Increased serum levels of cytokines released by cells of the immune response have been detected in patients suffering from dengue disease. Likewise, secondary infections by a different dengue virus serotype result in a highest risk of development of the severe dengue disease. Both findings suggest that the memory immune response is one of the key players in the pathogenesis of this disease. Here we take advantage of the particular Cuban epidemiological situation in dengue to analyze a broad spectrum of cell-mediated immune response mediators at mRNA and protein level. Evidences for a regulatory immune pattern in homologous (TGF-beta, IL-10) vs. pro-inflammatory pattern (IFN-gamma, TNF-alpha) in heterologous dengue virus re-challenge were found, suggesting a possible association with the higher incidence of severe dengue cases in the latter case.

History

Publication status

  • Published

Journal

Cellular Immunology

ISSN

0008-8749

Publisher

Elsevier

Issue

2

Volume

262

Page range

134-140

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-10-25