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Magnetization transfer ratio in gray matter: a potential surrogate marker for progression in early primary progressive multiple sclerosis
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posted on 2023-06-08, 12:51 authored by Zhaleh Khaleeli, Daniel R Altmann, Mara Cercignani, Olga Ciccarelli, David H Miller, Alan J ThompsonBACKGROUND Magnetization transfer imaging has the potential to provide a surrogate marker for progression in primary progressive multiple sclerosis (PPMS). OBJECTIVES To investigate whether brain magnetization transfer imaging, T2 lesion load, and atrophy changes over 3 years reflect concurrent clinical changes, and which baseline imaging measure best predicts progression over 3 years in early PPMS. DESIGN Prospective study. SETTING National Hospital for Neurology and Neurosurgery and the Institute of Neurology, London, England. PATIENTS Forty-seven patients with PPMS (of whom 43 completed the study) and 18 control subjects. INTERVENTIONS Brain magnetization transfer imaging (including T2-weighted images) and volume sequences every 6 months for 3 years. MAIN OUTCOME MEASURES Changes in Expanded Disability Status Scale (EDSS) score and associations with rate of change in imaging variables. RESULTS More rapid decline in gray matter mean and peak location magnetization transfer ratio and T2 lesion load increase were associated with greater rates of progression on the EDSS. Baseline gray matter peak height magnetization transfer ratio best predicted progression over 3 years. CONCLUSION Gray matter magnetization transfer ratio meets many of the criteria for a surrogate marker of progression in early PPMS.
History
Publication status
- Published
Journal
Archives of NeurologyISSN
1531-8249Publisher
American Medical AssociationExternal DOI
Issue
11Volume
65Page range
1454-1459Department affiliated with
- Clinical and Experimental Medicine Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-01Usage metrics
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