A highly sensitive radial diffusion measurement method for white matter tract investigation

Fasano, Fabrizio, Bozzali, Marco, Cercignani, Mara and Hagberg, Gisela E (2009) A highly sensitive radial diffusion measurement method for white matter tract investigation. Magnetic Resonance Imaging, 27 (4). pp. 519-530. ISSN 1873-5894

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This article describes a novel approach for local estimation of the radial diffusion coefficient (D(perpendicular)) in white matter (WM) regions containing well-oriented nervous fibers. The method is based on the assumption that the diffusion process in well-organized WM regions responds to a cylindrical symmetry. The increased precision in the estimation of D(perpendicular) provided by this local approach compared to standard techniques based on diffusion tensor imaging is demonstrated using numerical simulations. An in vivo validation of the technique is also provided, showing its application to the corpus callosum of six healthy volunteers, highlighting the sensitivity of the method. Assuming that D(perpendicular) is sensitive to myelin integrity, our technique has the potential to investigate pathophysiological aspects of several neurological and psychiatric disorders with improved precision in targeted WM tracts.

Item Type: Article
Keywords: Diffusion; DTI; Corpus callosum
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
Depositing User: Patricia Butler
Date Deposited: 29 Oct 2012 12:31
Last Modified: 26 Sep 2017 13:20
URI: http://srodev.sussex.ac.uk/id/eprint/41614
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