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Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively
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posted on 2023-06-08, 12:51 authored by Marco Bozzali, Mara Cercignani, F Baglio, G Scotti, E Farina, L Pugnetti, J Ashburner, R Nemni, A FaliniCorticobasal degeneration (CBD) presents with symptoms that often overlap with other neurological conditions. In many cases, diagnosis, prognosis and consequent clinical management remain uncertain. Structural and functional asymmetric brain changes represent the most consistent imaging findings that may assist in CBD diagnosis. Diffusion Tensor MRI (DT-MRI) is a quantitative technique that allows microscopic tissue abnormalities to be non-invasively assessed in vivo. A single case of clinically suspected CBD with symmetric diffuse brain atrophy on conventional-MRI scans was studied using DT-MRI by voxel-wise comparison with eight healthy subjects. The lateralized distribution of DT-MRI abnormalities was consistent with clinical features providing a substantial support to the diagnosis.
History
Publication status
- Published
Journal
Parkinsonism and Related DisordersISSN
1353-8020Publisher
ElsevierExternal DOI
Issue
5Volume
14Page range
436-439Department affiliated with
- BSMS Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-10-29Usage metrics
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