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Ali, Khalid, Rajkumar, Chakravarthi, Fantin, Francesco, Schiff, Rebekah and Bulpitt, Christopher J (2009) Irbesartan improves arterial compliance more than lisinopril. Vascular Health and Risk Management, 5 (4). pp. 587-592. ISSN 1178-2048
Full text not available from this repository.Abstract
BACKGROUND
Antihypertensive agents can reduce arterial stiffness. We hypothesized that an angiotensin receptor blocker (ARB) irbesartan and an angiotensin converting enzyme inhibitor (ACEI) lisinopril improved arterial compliance.
METHODS
A randomized, double-blind, double-dummy, controlled crossover trial. Fifteen hypertensive patients, mean age 65.5 +/- 8.9 years (mean +/- SD) were given irbesartan (150 to 300 mg/day) or lisinopril (10 to 20 mg/day) for 12 weeks and then crossed over for 12 weeks. Pulse wave velocity (PWV) in the carotid-femoral (CF), carotid-radial (CR), and femoral dorsalis-pedis (FD) were measured using a Complior((R)) PWV system.
RESULTS
After 12 weeks, systolic blood pressure (SBP) decreased from 162.4 +/- 12.9 to 134.5 +/- 14.8 with irbesartan and to 145.2 +/- 25 mmHg with lisinopril. Irbesartan and lisinopril reduced PWV (CF) in the elastic arterial system from 15.1 +/- 5 to 13.3 +/- 2.6 (p < 0.005) and to 14 +/- 4.7 (p < 0.05) m/s respectively (p = 0.345). Irbesartan reduced PWV (CR) and PWV (FD), whereas lisinopril did not. The difference between treatments was significant after SBP adjustment (p = 0.037 for PWV (CR) and p < 0.001 for PWV (FD)).
CONCLUSIONS
Irbesartan improved arterial compliance in elastic and muscular arteries, whereas lisinopril improved it only in elastic arteries.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine |
| Subjects: | R Medicine > RC Internal medicine > RC0581 Specialties of internal medicine > RC0952 Geriatrics |
| Related URLs: | |
| Depositing User: | Simone Breckell |
| Date Deposited: | 01 Nov 2012 15:01 |
| Last Modified: | 07 May 2013 14:33 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/41827 |