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Prooxidant-antioxidant balance in stroke patients and 6-month prognosis

journal contribution
posted on 2023-06-08, 13:33 authored by Mohammad Reza Parizadeh, Mahmoud Reza Azarpazhooh, Naser Mobarra, Mohsen Nematy, Dariush Hamidi Alamdari, Shima Tavalaie, Amirhossein Sahebkar, Bahareh Hassankhani, Gordon FernsGordon Ferns, Majid Ghayour-Mobarhan
BACKGROUND Oxidative stress is thought to play an important role in the pathogenesis of stroke. METHODS In the present study, we assessed the extent of oxidative stress in the sera of 120 patients in the first 24 hours after the onset of stroke and 80 healthy control subjects using a novel assay of prooxidant-antioxidant balance (PAB) that can measure the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby giving a redox index. RESULTS In stroke patients median serum PAB values were significantly higher than that of the control group [125.50 (103.36 - 151.80) vs 43.40 (29.77 - 77.01), p < 0.001]. However, no significant difference was observed between subgroups of patients with transient ischemic attack (TIA), cerebral infarction or cerebral hemorrhage (p > 0.05). Median Serum PAB values were not significantly different in patients with different outcomes based on their 6-month prognosis (p > 0.05). CONCLUSIONS We conclude that serum PAB values are elevated in patients with stroke, indicating a heightened state of oxidative stress, but do not distinguish between stroke types or predict 6-month prognosis.

History

Publication status

  • Published

Journal

Clinical Laboratory

ISSN

1433-6510

Issue

3-4

Volume

57

Page range

183-191

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-19

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