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Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin
journal contribution
posted on 2023-06-08, 13:39 authored by Jennifer M Bossert, Anna L Stern, Florence R M Theberge, Carlo Cifani, Eisuke KoyaEisuke Koya, Bruce T Hope, Yavin ShahamIn a rat model of context-induced relapse to heroin, we identified sparsely distributed ventral medial prefrontal cortex (mPFC) neurons that were activated by the heroin-associated context. Selective pharmacogenetic inactivation of these neurons inhibited context-induced drug relapse. A small subset of ventral mPFC neurons formed neuronal ensembles that encode the learned associations between heroin reward and heroin-associated contexts; re-activation of these neuronal ensembles by drug-associated contexts during abstinence provoked drug relapse
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Publication status
- Published
Journal
Nature NeuroscienceISSN
1097-6256Publisher
Nature Publishing GroupExternal DOI
Issue
4Volume
14Page range
420-422Department affiliated with
- Psychology Publications
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- No
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- Yes
Legacy Posted Date
2012-11-14Usage metrics
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