Rahsepar, Amir Ali, Mirzaee, Asadollah, Moodi, Fatemeh, Moohebati, Mohsen, Tavallaie, Shima, Khorashadizadeh, Fatemeh, Eshraghi, Ali, Alavi, Maryam-Sadat, Zarrabi, Laya, Sajjadian, Mostafa, Amini, Maral, Khojasteh, Roshanak, Paydar, Roghayeh, Mousavi, Somayeh, Ghayour-Mobarhan, Majid and Ferns, Gordon A (2012) Changes in anti-heat shock protein 27 antibody and C-reactive protein levels following cardiac surgery and their association with cardiac function in patients with cardiovascular disease. Cell stress & chaperones, 17 (4). ISSN 1466-1268

Full text not available from this repository.

Abstract

The relationship between serum anti-heat shock protein (Hsp)27 antibody and high sensitive C-reactive protein (hs-CRP) levels and indices of cardiac function were investigated in patients undergoing coronary artery bypass grafting (CABG) or heart valve replacement. The changes in anti-Hsp27 antibody titers and hs-CRP levels were compared among patients undergoing off-pump and on-pump CABG or valvular heart replacement. Fifty-three patients underwent off-pump, on-pump CABG, and heart valvular replacement in each group. Serum anti-Hsp27 titers and hs-CRP values were measured 24 h before and after the operation and at discharge. Echocardiography was performed before surgery and before discharge. The results were compared with values from 83 healthy controls. hs-CRP levels increased and anti-Hsp27 antibody decreased following surgery (P < 0.001 and P < 0.05, respectively), although these changes were independent of operative procedure (P = 0.361 and P = 0.120, respectively). Anti-Hsp27 antibody levels were higher at the time of discharge (P = 0.016). Only in coronary patients were anti-Hsp27 antibody levels negatively associated with E/E' (r = -0.268, P = 0.022), a marker of pulmonary capillary wedge pressure. In conclusions, anti-Hsp27 antibody levels are associated with indices of cardiac function in coronary patients. Cardiopulmonary bypass had no significant effect on the induction of changes in anti-Hsp27 levels. Moreover, anti-Hsp27 antibody levels fell in all groups postoperatively; this may be due to the formation of immune complexes of antigen-antibody, and antibody levels were higher at the time of discharge.

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Division of Medical Education
Subjects:	R Medicine > R Medicine (General) > R735 Medical education
Depositing User:	Gordon Ferns
Date Deposited:	16 Nov 2012 14:32
Last Modified:	16 Nov 2012 14:32
URI:	http://srodev.sussex.ac.uk/id/eprint/42621

📧 Request an update