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A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant-antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease

journal contribution
posted on 2023-06-08, 13:46 authored by Amirhossein Sahebkar, Hossein Pourghadamyari, Mohsen Moohebati, Seyed Mohammad Reza Parizadeh, Homa Falsoleiman, Mashallah Dehghani, Afsoon Fazlinezhad, Saeed Akhlaghi, Shima Tavallaie, Roghayeh Paydar, Majid Ghayour-Mobarhan, Gordon FernsGordon Ferns
OBJECTIVE To investigate the association between serum antibody titers to Hsp27 (anti-Hsp27) and pro-oxidant-antioxidant balance (PAB) in patients with angiographically-defined coronary artery disease (CAD) with or without the metabolic syndrome (MS). DESIGN Subjects (n=243) were classified into MS+ (n=161) and MS- (n=82) subgroups, based on the AHA/NHBLI criteria. RESULTS Serum anti-Hsp27 titers were found to be significantly higher in the MS+ vs. MS- group. However, no significant difference was observed in serum PAB values. When assessed for individual components of MS, increased serum anti-Hsp27 was found to be higher in subgroups with elevated triglycerides, elevated blood pressure and reduced high-density lipoprotein cholesterol (HDL-C). Subgroups of patients with elevated triglycerides had higher PAB values. HDL-C was the only significant predictor of anti-Hsp27 in the population as a whole. CONCLUSION The evidence from this investigation indicates the presence of elevated anti-Hsp27 in patients with concurrent CAD and MS compared to those with CAD alone.

History

Publication status

  • Published

Journal

Clinical Biochemistry

ISSN

0009-9120

Publisher

Elsevier

Issue

17-18

Volume

44

Page range

1390-1395

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-16

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