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Prooxidant-anti-oxidant balance is not associated with extent of coronary artery disease

journal contribution
posted on 2023-06-08, 13:46 authored by Amir Ali Rahsepar, Hossein Pourghadamyari, Mohsen Moohebati, Seyyed Mohammad Reza Parizadeh, Shima Tavallaie, Roghayeh Paydar, Homa Falsoleiman, Mashalla Dehghani, Afsoon Fazlinezhad, Maral Amini, Fatemeh Khorashadizadeh, Majid Ghayour-Mobarhan, Gordon FernsGordon Ferns
OBJECTIVE We have measured the pro-oxidant-antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects. DESIGN AND METHODS Based on angiography results, 400 patients with stable CAD were divided into CAD- and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD). RESULTS The mean PAB values in the healthy subjects, was significantly lower than for other groups (P<0.001). In CAD- patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P>0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P>0.05). CONCLUSIONS In conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels.

History

Publication status

  • Published

Journal

Clinical Biochemistry

ISSN

0009-9120

Publisher

Elsevier

Issue

16

Volume

44

Page range

1304-1308

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-19

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