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Rahsepar, Amir Ali, Pourghadamyari, Hossein, Moohebati, Mohsen, Parizadeh, Seyyed Mohammad Reza, Tavallaie, Shima, Paydar, Roghayeh, Falsoleiman, Homa, Dehghani, Mashalla, Fazlinezhad, Afsoon, Amini, Maral, Khorashadizadeh, Fatemeh, Ghayour-Mobarhan, Majid and Ferns, Gordon A (2011) Prooxidant-anti-oxidant balance is not associated with extent of coronary artery disease. Clinical biochemistry, 44 (16). pp. 1304-8. ISSN 1873-2933
Full text not available from this repository.Abstract
OBJECTIVE
We have measured the pro-oxidant-antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects.
DESIGN AND METHODS
Based on angiography results, 400 patients with stable CAD were divided into CAD- and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD).
RESULTS
The mean PAB values in the healthy subjects, was significantly lower than for other groups (P<0.001). In CAD- patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P>0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P>0.05).
CONCLUSIONS
In conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Division of Medical Education |
| Subjects: | R Medicine > R Medicine (General) > R735 Medical education |
| Related URLs: | |
| Depositing User: | Gordon Ferns |
| Date Deposited: | 19 Nov 2012 09:37 |
| Last Modified: | 19 Nov 2012 09:37 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/42644 |