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Simvastatin treatment reduces heat shock protein 60, 65, and 70 antibody titers in dyslipidemic patients: A randomized, double-blind, placebo-controlled, cross-over trial

journal contribution
posted on 2023-06-08, 13:46 authored by Mohsen Moohebati, Shirin Bidmeshgi, Mahmoud R Azarpazhooh, Mahdi Hassanzadeh Daloee, Majid Ghayour-Mobarhan, Shima Tavallaie, Maral Amini, Akram Momenzadeh, Amirhossein Sahebkar, Roghayeh Paydar, Amir A Rahsepar, Seyyed M R Parizadeh, Saeed Akhlaghi, Gordon FernsGordon Ferns
OBJECTIVE This study aimed to evaluate the effects of statin therapy on serum levels of antibodies to several specific heat shock proteins (HSPs) in dyslipidemic patients. DESIGN AND METHODS Participants (n=102) were treated with simvastatin (40mg/day), or placebo in a randomized, double-blind, placebo-controlled, cross-over trial. Anti-HSP60, 65, 70, and hs-CRP levels were measured before and after each treatment period. Seventy-seven subjects completed the study. RESULTS Treatment with simvastatin was associated with significant reductions in serum anti-HSP60, 65, and 70 titers in the dyslipidemic patients (10%, 14%, and 15% decrease, respectively) (p<0.001). There have been previous reports of reductions in serum CRP with statin treatment, and although median CRP levels were 9% lower on simvastatin treatment, this did not achieve statistical significance. CONCLUSION While it is unclear whether HSP antibodies are directly involved in atherogenesis, our findings suggest that simvastatin inhibits autoimmune responses that may contribute to the development of cardiovascular disease

History

Publication status

  • Published

Journal

Clinical Biochemistry

ISSN

0009-9120

Publisher

Elsevier

Issue

2-3

Volume

44

Page range

192-197

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-19

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