Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation

Tara, Fatemeh, Rayman, Margaret P, Boskabadi, Hassan, Ghayour-Mobarhan, Majid, Sahebkar, Amirhossein, Alamdari, Daryoush H, Razavi, Behjat S, Tavallaie, Shima, Azimi-Nezhad, Mohsen, Shakeri, Mohammad T, Oladi, Mohammadreza, Yazarlu, Omid, Ouladan, Shaida, Sangani, Maryam Teimoori, Omran, Fatemeh Rezagholizadeh and Ferns, Gordon (2010) Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation. Journal of Perinatal Medicine, 38 (5). pp. 473-478. ISSN 1619-3997

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We assessed the impact of selenium, a trace element with antioxidant properties on a simple measure of oxidative stress in pregnant women.


A novel assay of prooxidant-antioxidant balance (PAB) was applied in a double-blind, placebo-controlled study of selenium supplementation in pregnancy. We measured the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby calculating a redox index. A total of 166 primigravid pregnant women in the first trimester of pregnancy, were randomized to receive 100 microg of selenium (n=83) or placebo (n=83) per day until delivery. PAB values and serum selenium concentrations were measured at baseline and at the end of study.


Pretreatment demographic data and biochemical indices including serum selenium concentrations did not differ significantly between the groups. The drop-out rates for the groups were 22/83 and 19/83 for the selenium and placebo groups, respectively. Supplementation with selenium was associated with a significant increase in mean serum selenium concentration (P<0.001) but without significant change in mean PAB value. In contrast, mean serum selenium concentration remained unchanged and mean PAB values increased significantly (P<0.05 in the control group).


Our findings suggest that selenium supplementation may reduce oxidative stress associated with pregnancy

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > R Medicine (General) > R735 Medical education
Depositing User: Gordon Ferns
Date Deposited: 19 Nov 2012 06:51
Last Modified: 19 Nov 2012 06:51
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