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Serum high-sensitivity C-reactive protein and heat shock protein 27 antibody titers in patients with stroke and 6-month prognosis

journal contribution
posted on 2023-06-08, 13:47 authored by Mahmoud Reza Azarpazhooh, Naser Mobarra, Syyed Mohammad Reza Parizadeh, Shima Tavallaie, Mahsa Bagheri, Amir Ali Rahsepar, Majid Ghayour-Mobarhan, Amirhossein Sahebkar, Gordon FernsGordon Ferns
Serum heat shock protein 27 immunoglobulin G (IgG) antibody titers (anti-HSP27) and high-sensitivity C-reactive protein (hsCRP) concentrations were measured in samples from 168 patients in the first 24 hours after the onset of stroke and 80 age-and sex-matched control participants. In patients with stroke, median serum anti-HSP27 titer was significantly higher than that of the control group (0.18 [0.14-0.28] vs 0.08 [0.04-0.12], P < .001). Median serum hsCRP concentration was also significantly higher in patients compared with the control group (11.43 [8.07-13.53] vs 3.23 [1.66-6.24], P < .001). Serum anti-HSP27 and hsCRP concentrations did not differ significantly among patients with different stroke types. Neither serum anti-HSP27 nor hsCRP levels predicted 6-month prognosis in the patients with stroke. We conclude that serum anti-HSP27 titers and hsCRP concentrations are elevated in patients with stroke but do not distinguish between stroke types or predict 6-month prognosis.

History

Publication status

  • Published

Journal

Angiology

ISSN

1940-1574

Publisher

Sage

Issue

6

Volume

61

Page range

607-612

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-19

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